Publications
Stearoyl-CoA desaturase-1: a potential therapeutic target for neurological disorders, Mol. Neurodegener. (2024).
doi: 10.1186/s13024-024-00778-w.
Loix M, Vanherle S, Turri M, Kemp S, Fernandes K, Hendriks J, Bogie J.
Central inhibition of stearoyl-CoA desaturase has minimal effects on the peripheral metabolic symptoms of the 3xTg Alzheimer's disease mouse model. (2024). doi: 10.1038/s41598-024-58272-8.
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Hamilton L, M`Bra P, Mailloux S, Galoppin M, Aumont A, Fernandes K.
Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse model. Nat Commun 13, 2061 (2022). https://doi.org/10.1038/s41467-022-29506-y
Hamilton L, Moquin-Beaudry G, Mangahas C, Pratesi F, Aubin M, Aumont A, Joppé S, Légiot A, Vachon A, Plourde M, Mournier C, Tetreault M, Fernandes K.
Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's disease. Theranostics. (2020). 10(14):6337-6360. doi: 10.7150/thno.44962.
Syal C, Kosaraju J, Hamilton L, Aumont A, Chu A, Sarma SN, Thomas J, Seegobin M, Dilworth FJ, He L, Wondisford FE, Zimmermann R, Parent M, Fernandes K, Wang J.
Genetic targeting of neural precursors in the adult forebrain ventricular epithelium. Life Sci Alliance. (2020). 3(7):e202000743.
doi: 10.26508/lsa.202000743.
Joppé SE*, Cochard LM*, Levros LC Jr, Hamilton LK, Ameslon P, Aumont A, Barnabé-Heider F, Fernandes KJ.
Modeling Late-Onset Sporadic Alzheimer's Disease through BMI1 Deficiency. Cell Rep. (2018). 23(9):2653-2666.
Flamier A, El Hajjar J, Adjaye J, Fernandes KJ, Abdouh M, Bernier G.
RNA-Sequencing Reveals Unique Transcriptional Signatures of Running and Running-Independent Environmental Enrichment in the Adult Mouse Dentate Gyrus. (2018). Front Mol Neurosci. 11:126.
Grégoire CA, Tobin S, Goldenstein BL, Samarut É, Leclerc A, Aumont A, Drapeau P, Fulton S, Fernandes KJL.
FoxJ1 regulates spinal cord development and is required for the maintenance of spinal cord stem cell potential. (2018). Exp Cell Res. 368(1):84-100.
Li X, Floriddia EM, Toskas K, Chalfouh C, Honore A, Aumont A, Vallières N, Lacroix S, Fernandes KJL, Guérout N, Barnabé-Heider F.
Neural stem cells and adult brain fatty acid metabolism: Lessons from the 3xTg model of Alzheimer's disease. (2018). Biol Cell 110(1):6-25.
Hamilton LK & Fernandes KJL.
Fate Through Fat: Neutral Lipids as Regulators of Neural Stem Cells. (2017). Book Chapter In: Pébay, A., Wong, R. (eds) Lipidomics of Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, pp 87-115.. https://doi.org/10.1007/978-3-319-49343-5_5
Hamilton L. & Fernandes K,
Regenerative potential of ependymal cells for spinal cord injuries over time. (2016). EBioMedicine 13:55-65
Li X, Floriddia EM, Toskas K, Fernandes KJ, Guérout N, Barnabé-Heider F.
Bone morphogenetic protein dominantly suppresses epidermal growth factor-induced proliferative expansion of adult forebrain neural precursors. (2015). Front Neurosci 9:407.
Joppe SE, Hamilton LK, Cochard LM, Levros LC, Aumont A, Barnabé-Heider F, Fernandes KJL.
Aberrant lipid metabolism in the forebrain niche suppresses adult neural stem cell proliferation in an animal model of Alzheimer's disease. (2015). Cell Stem Cell 17(4):397-411
Hamilton LK, Dufresne M, Joppé SE, Petryszyn S, Aumont A, Calon F, Barnabé-Heider F, Furtos A, Parent M, Chaurand P, Fernandes KJL.
Endogenous neural stem cell responses to stroke and spinal cord injury. (2015). Glia 63(8): 1469-82
Grégoire CA, Goldenstein BL, Florridia EM, Barnabé-Heider F, Fernandes KJL.
Central canal ependymal cells proliferate extensively in response to traumatic spinal cord injury but not demyelinating lesions. (2014). Plos One 9(1): e85916
Lacroix S, Hamilton LK, Vaugeois A, Beaudoin S, Breault-Dugas C, Pineau I, Lévesque SA, Grégoire CA, Fernandes KJL
Untangling the influences of voluntary running, environmental complexity, social housing and stress on adult hippocampal neurogenesis. (2014). Plos One 9(1): e86237
Grégoire CA, Bonenfant D, Le Nguyen A, Aumont A, Fernandes KJL
Aging and neurogenesis in the adult forebrain: what we have learned and where we should go from here. (2013). European Journal of Neuroscience 37: 1978–1986
Hamilton LK, Joppé SE, Cochard LM, Fernandes KJL.
Mammalian target of rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain. (2012). Journal of Neuroscience 32(43):15012-26
Paliouras GN, Hamilton LK, Aumont A, Joppé SE, Barnabé-Heider F, Fernandes KJL.
Genotype analysis of tumor-initiating cells expressing CD133 in neuroblastoma. (2012). Genes, Chromosome and Cancer 51(8):792-804
Cournoyer S, Nyalendo C, Addioui A, Belounis A, Beaunoyer M, Aumont A, Teira P, Duval M, Fernandes K, Fetni R, Haddad E, Sartelet H.
Aging of the subventricular zone neural stem cell niche: evidence for quiescence-associated changes between early and mid-adulthood. (2011). Neuroscience 173:135-149
Bouab M, Paliouras GN, Aumont A, Forest-Bérard K, Fernandes KJL.
Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease. (2011). European Journal of Neuroscience 32(6):905-920
Hamilton LK, Aumont A, Julien C, Vadnais A, Calon F, Fernandes KJL.
Distinct stages of adult hippocampal neurogenesis are regulated by running and the running environment (2011). Hippocampus. 21(12):1334-1347
Bednarczyk M, Hacker LC, Fortin-Nunez S, Aumont A, Bergeron R, Fernandes KJL.
Cellular organization of the central canal ependymal zone, a niche of latent neural stem cells in the adult mammalian spinal cord. (2009). Neuroscience 164:1044-1056
Hamilton LK, Truong MKV, Bednarczyk M, Aumont A., Fernandes KJL
Prolonged voluntary wheel-running stimulates neural precursors in the hippocampus and forebrain of adult CD1 mice. (2009). Hippocampus, 19(10):913-27
Bednarczyk M, Aumont A, Décary S, Bergeron R, Fernandes KJL.
The rat heart contains a neural stem cell population; role in sympathetic sprouting and angiogenesis. (2008). Journal of Molecular and Cellular Cardiology 45(5):694-702
El-Helou V, Beguin PC, Assimakopoulos J, Clement R, Gosselin H, Brugada R, Aumont A, Biernaskie J, Villeneuve L, Fernandes KJL, Calderone A.
Multipotent skin-derived precursors: adult neural crest-related precursors with multilineage differentiation potential. (2008). Philos Trans R Soc Lond B Biol Sci. 363 (1489):185-98
Fernandes KJL, Toma JG, Miller FD.
Analysis of the neurogenic potential of multipotent Skin-derived Precursors. (2006). Exp Neurol 201(1): p. 32-48
*equal contributions
Fernandes KJL*, Kobayashi NR*, Gallagher CJ, Barnabé-Heider F, Aumont A, Kaplan DR, Miller FD.
Evidence that embryonic neurons regulate the onset of gliogenesis via cardiotrophin-1. (2005). Neuron 48:253-265
Barnabé-Heider F, Wasylnka JA, Fernandes KJL, Porsche C, Sendtner M, Kaplan DR, Miller FD.
A transcriptional role for C/EBP beta in the neuronal response to axonal injury. (2005). Mol Cell Neurosci 29(4):525-535
Nadeau S*, Hein P*, Fernandes KJL, Peterson AC, Miller FD.
A dermal niche for multipotent adult skin-derived precursor cells. (2004). Nat Cell Biol 6(11):1082-1093
*equal contributions.
Fernandes KJL*, McKenzie IA*, Mill P, Smith K, Akhavan M, Barnabé-Heider F, Biernaski J, Junek A, Kobayashi NR, Toma JG, Kaplan DR, Labosky PA, Rafuse V, Hui CC, Miller FD.
Axonal re-injury reveals the survival and re-expression of regeneration associated genes in chronically axotomized adult mouse motoneurons. (2004). Exp Neurol 188(2):331-40
McPhail LT, Fernandes KJL, Chan CCM, Vanderluit JL, Tetzlaff W
In vivo application of mitochondrial pore inhibitors blocks the induction of apoptosis in axotomized neonatal facial motoneurons. (2003). Cell Death Diff 10:969-976
Vanderluit JL, McPhail LT, Fernandes KJL, Kobayashi NR, Tetzlaff W.
Isolation of multi-potent adult stem cells from the dermis of mammalian skin. (2001). Nat Cell Biol 3(9):778-784 *equal contributions
Toma JG, Akhavan M*, Fernandes KJL*, Barnabe-Heider F, Sadikot A, Kaplan DR, Miller FD.
Fibroblast growth factor treatment produces differential effects on survival and neurite outgrowth from identified bulbospinal neurons in vitro. (2000). Exp Neurol 163(2):357-72
Pataky DM, Borisoff JF, Fernandes KJ, Tetzlaff W, Steeves JD (2000).
Caspase-3 is activated following axotomy of neonatal facial motoneurons and caspase-3 gene deletion delays axotomy-induced cell death in rodents. (2000). Eur J Neurosci 12(10):3469-80
Vanderluit JL, McPhail LT, Fernandes KJ, McBride CB, Huguenot C, Roy S, Robertson GS, Nicholson DW, Tetzlaff W.
Influence of the axotomy to cell body distance in rat rubrospinal and spinal motoneurons: differential regulation of GAP-43, tubulins, and neurofilament-M. (1999). J Comp Neurol 414:495-510
Fernandes KJL, Fan D-P, Tsui BJ, Cassar SL, Tetzlaff W.
Acetylcholinesterase gene expression in axotomized rat facial motoneurons is differentially regulated by neurotrophins: correlation with trkB and trkC mRNA levels and isoforms. (1998). J Neurosci.18(23):9936-47
Fernandes KJL, Kobayashi NR, Jasmin BJ, Tetzlaff W.